Título

ASSOCIATIONS AMONG VISUAL FUNCTION AND QUALITY OF LIFE IN PATIENTS WITH VOGT-KOYANAGI-HARADA DISEASE

Objetivo

To evaluate the associations between visual acuity, disease activity, treatment and visual function with self-reported quality of life metrics in patients with Vogt-Koyanagi-Harada (VKH) disease.

Método

Patients with VKH disease with minimum 12-month follow-up from acute onset were evaluated. Disease activity was detected by clinical examination and complementary exams. Visual function was measured by best corrected visual acuity (BCVA), full-field ERG and contrast sensitivity (CS). The self-reported quality of life was assessed by the NEI VFQ-25 and SF-36 questionnaires. The data were analyzed with Mann-Whitney and Spearman's rho tests.

Resultado

19 patients were evaluated (17F/2M; mean age 36.9±12.7y). BCVA was 20/20 in 63.1% and ≥20/60 in 94.7% of patients. In SF36 questionnaire, immunosuppressive therapy impacted negatively in physical and social functioning, bodily pain and vitality scores (p<0.05), while higher cumulative corticosteroids dose had negative impact in role physical and social function scores (p<0.01). Worsening full-field scotopic ERG parameters had negative effect on role physical, vitality and social functioning scores (p<0.01). In NEI-VFQ-25 questionnaire negative impact on general vision was related with worse BCVA (p<0.01), its fluctuation (p<0.05), choroidal thickness fluctuation (p<0.05) and higher cumulative corticosteroids dose (p<0.01). Lower CS had negative impact on peripheral and distance vision (p<0.01).

Conclusão

VR-QoL and HR-QoL questionnaires together with psychophysical measurements of visual impairment bring a more extensive understanding of the impact of choroidal inflammation and treatment in patients with VKH disease.