Título

HIGH DENSITY PERIMETRY AND FOVEAL AVASCULAR ZONE IN GLAUCOMA

Objetivo

Evaluate structure and function association between macular high density perimetry (Octopus Macular program) and foveal avascular zone (FAZ), macular vascular density (VD) and ganglion cells layer (GCL) in glaucoma patients.

Método

93 eyes (47 patients) were included. Perimetry was performed using Octopus 900 Macular program that includes high-density stimuli: 45 points one degree spacing in the fovea (central 4 degrees) and 36 points radially oriented from 4 to 10 degrees. FAZ, VD and GCL were evaluated using Triton angio-OCT. Vascular parameters were: FAZ area, perimeter and circularity as also macular VD. VF variables were MD, MS, sLV and GCL evaluation included total, superior and inferior means. Vascular parameters were considered dependent variables and GCL independent for structure/structure analysis. For structure/function analysis VF parameters were dependent variables and vascular parameters, independent. GEE was used as both eyes entered in all models and uni and multivariable analysis were performed. FAZ parameters were automatically calculated using ImageJ software.

Resultado

25 women were included, mean age was 66,67 (+/-7,36). Mean of MS was 23,25 (+/-5.53) and mean central GCL was 57,07 microns (+/-7.24). MD and MS were significant associated with FAZ area, circularity, and perimeter as also superior and inferior macular VD (P<0.05), sLV was not associated with any vascular parameter. For structure/structure analysis, significant associations were found between FAZ area and superior GCL(P<0.05). FAZ perimeter, circularity and superior VD were significantly associated with GCL parameters (P<0.05). When multivariable analysis was performed for VF parameters (MS and MD), perimetry and temporal vascular density was significant associated (P<0.05).

Conclusão

When using high density perimetry, many VF parameters were associated with FAZ alterations in glaucoma patient. Region of interest approach could be used in clinical practice for better structure and function evaluation.